Showing 1-20 of 29 results

• Andreas Barth's research group

  Research group

  Our group works at the intersection between basic and applied biophysics using experimental and computational methods.

• Anna Forsby's research group

  Research group

  The main interest our research group is the study mechanisms for chemically induced acute, developmental neurotoxicity by using neuronal cell models. The usefulness of the cell models for risk assessment is evaluated by integrating in vitro data from the cell models with in vivo data from rat and clinical observations from human in predictions models.

• Anna-Lena Ström's research group

  Research group

  Neurodegenerative diseases like Amyotrophic lateral sclerosis (ALS), Alzheimer’s and polyglutamine diseases are characterized by the gradual loss of neurons in the central nervous system (CNS). While these disorders are distinct in their clinical manifestations, they share pathological hallmarks like protein misfolding, aggregation and oxidative stress.

• Arne Elofsson's research group

  Research group

  Combining large scale life-science data with artificial intelligence is crucial for the continued progression of our understanding of the molecular processes that govern life. We propose developing novel deep-learning methods to provide an unprecedented accurate description of the human proteome.

  

• Astrid Gräslund's research group

  Research group

  The Gräslund group works on two groups of biomolecules - ribonucleotide reductase and bioactive peptides - with a special focus on their membrane interactions. The aim is to relate structure, dynamics, and interactions studied by spectroscopy to the biological reactions and functions.

• Bengt Mannervik's research group

  Research group

  Enzymology is a cornerstone in the molecular life sciences. Rates of chemical reactions in cells and cellular signaling are governed by enzymes. It is becoming increasingly evident that enzymes are integral components of more wide-ranging molecular interactions such that the study of enzyme functions should be extended to their cellular context.

• Britt-Marie Sjöberg's research group

  Research group

  The enzyme ribonucleotide reductase (RNR) catalyses the reaction that provides new DNA building blocks. RNR is therefore a prerequisite in all living cells, and also regulates cellular replication and proliferation. Some antiproliferative drugs (e.g. hydroxyurea and gemcitabine) that are used clinically today are specific inhibitors of RNR.

  

• Christian Broberger's research group

  Research group

  In our laboratory, we are interested in the organization of brain circuits that control innate behaviours, such as aggression, reproduction, feeding as well as sleep. These circuits often originate in the hypothalamus, an evolutionarily old part of the brain, and include the neuroendocrine system, the interface between the brain and the endocrine system.

• Daniel Daley's research group

  Research group

  Research in the Daley laboratory explores how proteins are trafficked, folded and assembled in bacterial cell factories. The research provides molecular insight into fundamental processes, such as protein secretion and cell division. The knowledge gained in these studies is used to engineer more efficient bacterial cell factories.

• David Drew's research group

  Research group

  The Drew group investigates the alternating-access mechanism of solute transporters for sugars and ions. These transporters are critical to cell homeostasis and their dysfunction is associated with human diseases, such as cancer and diabetes.

• Einar Hallberg's research group

  Research group

  Human diseases such as cancer have been tied to proteins in Nuclear Pore Complexes (NPC). It has become increasingly clear that the proteins of the nuclear envelope orchestrate many functions involving cell signalling and chromatin organisation. The Hallberg Group is progressing on the path of discerning the nature of the pivotal role these proteins serve.

  

• Erik Lindahl's research group

  Research group

  Our research is focused on understanding the doors and windows of our cells in the form of membrane proteins in general, and in particular the functions of ion channels and pumps that transport ions to make our nervous system work.

• Erik Sonnhammer's research group

  Research group

  We are only starting to understand the functional networks of the proteins encoded in the now sequenced human genome. The group is addressing this issue using computational approaches, such as hidden Markov models, evolutionary models, and discriminant statistical methods - aiming to predict function, both with regards to biochemical activity and pathways.

• Eva Hedlund's research group

  Research group

  We are focused on understanding mechanisms of selective neuronal vulnerability and resilience in neurodegenerative diseases, with particular emphasis on the lethal motor neuron disease amyotrophic lateral sclerosis (ALS).

  

• Gunnar von Heijne's research group

  Research group

  Membrane proteins serve a number of very important functions in both prokaryotic and eukaryotic cells. They are built according to structural principles different from those of globular proteins.

  

• Henrietta Nielsen's research group

  Research group

  Alzheimer’s disease followed by dementia with Lewy bodes is the main cause of neurodegenerative dementia. The neuropathological hallmarks for these disorders are different, but still share many similarities. In our group we investigate biological mechanisms promoting/leading to neurodegenerative dementia.

• Iskra Pollak-Dorocics research group

  Research group

  The immense complexity of the brain emerges from its vast connectivity and cell type diversity. We study the diversity of neuromodulatory neurons and circuits in the brain. By using a combination of molecular and system neuroscience tools to visualize, record and manipulate neural populations, we aim to understand their particular contribution to behavior.

• Jan-Willem de Gier's research group

  Research group

  Our most important goal is to identify the bottlenecks hampering protein production and utilise this information to further engineer bacterial strains with improved production characteristics.

  

• Lena Mäler's research group

  Research group

  For many years, the Mäler group has focused on biophysical investigations of the interactions between membrane proteins and lipids - a crucial but in some ways experimentally intractable area of research. We explore different aspects of these interactions; protein structure and, lipid dynamics and their dependence on interactions with membrane proteins.

• Marek Bartosovic's research group

  Research group

  The Bartosovic group is interested in epigenetic programs that regulate gene expression in the central nervous system.