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Showing 1-20 of 26 results
The APOE4 allele is the strongest genetic risk factor for sporadic Alzheimer´s disease (AD). How APOE4 increases the risk of AD is despite ample research still not fully understood. Apolipoprotein E (apoE), the protein product of APOE, is a major lipid carrier and accumulating evidence points to a prominent role of lipid metabolism in the etiology of AD.
No man (or woman) is an island. We cooperate, we fight, we make friends and we raise our young; all selected from a repertoire of social behaviours that afford us opportunities for learning, access to food and possibilities to reproduce. To understand how social behavior is organized constitutes a critical step towards understanding ourselves.
The objective of this project is to map modes of action for developmental neurotoxicity (DNT) by using human neuroblastoma SH-SY5Y and mouse neural progenitor C17.2 cell lines, with the aim to establish non-animal methods as alternatives to regulatory test guidelines.
We propose to study the clostridial neurotoxins, a family of protein toxins that include the closely related tetanus and botulinum neurotoxins, which are the most toxic substances known. Even though these toxins can be deadly, the botulinum neurotoxins are extensively used therapeutically.
The great majority of integral membrane proteins are cotranslationally inserted in the inner bacterial membrane or the eukaryotic endoplasmic reticulum membrane with the aid of the SecYEG translocon in bacteria or the homologous Sec61 translocon in eukaryotes.
Spatially resolved omic technologies enable mapping the spatial organization of tissues at the molecular level and are thus fundamental to understand how complex multicellular organisms work and how they are disrupted by diseases such as cancer.
The respiratory chain of mitochondria and aerobic bacteria is composed of membrane-bound enzymes that transfer electrons from a donor, NADH, to an acceptor, O2. The sequential electron transfer through these complexes is linked to transmembrane proton translocation, which maintains an electrochemical proton gradient that is used to store free energy.
The network activity patterns of the CNS result from an interplay between intrinsic neuronal properties and the connections formed by cells. It is now clear that electrical synapses formed by intercellular connexin channels in gap junctions are common in the mammalian CNS, influencing circuit activity. But exactly how it shapes brain output remains elusive.
We will search for novel antibiotics against human pathogens with the enzyme ribonucleotide reductase (RNR) as a target. RNR is essential to all free-living organisms and provides building blocks for DNA synthesis.
Early diagnosis dramatically increases the survival rates of cancers. The merging of advanced diagnostics with therapeutics is poised to reshape the future of cancer care. Our vision is to take the functionalization of optical fibers, creating a palette of novel components and methods beyond state-of-the-art.
Biological energy transduction is catalyzed by membrane-bound enzymes that capture and convert chemical or light-energy to power cellular function. This project aims to elucidate how modular adaptations enable energy transducing enzymes to evolve new biological functionality.
The aim is to introduce a new type of genotype-phenotype diagnostic assay that will be applied to tumor types where personalised diagnostics is clinically relevant. We will also create 3D models of genetically heterogeneous tumors with respect to their full cellular content.
Enzymes utilize metal and radical cofactors to perform particularly challenging chemistry in energy conversion, chemical synthesis and for harvesting sunlight. If we could mimic these processes it would eliminate the need for fossil fuels and transform chemical industry while reducing its environmental impact.
Developmental disorders are often debilitating and untreatable, resulting in great suffering. We have formed a Swedish consortium – the Human Developmental Cell Atlas: a comprehensive molecular atlas of human prenatal development, describing every cell type in molecular detail and showing the spatial distribution of cells in three dimensions and over time.
Membrane proteins are of exceptional importance for transport and signalling in the cell, and pumps and channels in particular are key examples of proteins that adopt different conformational states as part of cycles that define their function.
High-throughput biology (genomics, proteomics, transcriptomics, metabolomics, etc.) is producing massive amounts of biological data that in different ways can help us understand biology. A major challenge is to turn this Big Data into knowledge that generates novel biological insights.
The aim is to understand the role of nuclear membrane proteins in chromatin organization and cell differentiation, which have impact on aging and diseases associated with loss of heterochromatin and thus dysregulated gene expression.
